Likewise, a high concentration of trehalose induced cytotoxic effects, an effect also observed in previous studies (Lan et al., 2012 Table 1). In contrast, at a high concentration (higher than 1 mM), trehalose induced the expression of A53T α‐synuclein and attenuated cell viability through stabilization of A53T α‐synuclein oligomers (Zhao et al., 2017 Table 1). So too much Trehalose is BAD: /pmc/articl.Ī recent study has demonstrated that trehalose decreased the A53T α‐synuclein expression level in transduced PC12 cells at low concentration (lower than 1 mM). I don't know if I am going to be able to resist this. That's only twice the recommended dose on the first sodium butyrate capsules I found and a quick search easily found a study where they were giving people 4 grams of sodium butyrate a day /pmc/articl. Using the park_bear adjustment factor for metabolic rate (divide dose by 12 to adjust from mouse to human, and by 8 for rats) for a 70 kg person (me) that would be taking trehalose (4x70/8) 35 grams (that is less than 2 tablespoons full I think) and sodium butyrate (300x70/8) 2625 mg. Α-syn was used to induce PD in wistar rats, which were thereafter subjected to treatment with trehalose (tre, 4g/kg, orally), a potent autophagy inducer and sodium butyrate (SB, 300 mg/kg, orally), a pan histone deacetylase inhibitor alone as well as in combination. I hope you share some of your newer findings, Joe!Īnd then there is this: Neuroprotective Effects of Trehalose and Sodium Butyrate on Preformed Fibrillar Form of α-Synuclein-Induced Rat Model of Parkinson’s Disease - 2021 /doi/10.1021/ac. I absolutely agree that the medical community has nothing to slow the disease process and if that is what you seek, then you will have to look elsewhere, such as this forum as one example. If the risk seems low enough then it may be worth testing, but if the perceived risk is too high for the individual, then maybe not. I think it is useful to know what the risks might be, before starting something. Just swallowing a pill confers the risk of choking in a person who has swallowing issues as is sometimes seen in PwP. Even exercise has some risk involved such as falling while walking or losing your balance on a treadmill and falling off. It seems that everything used for PD has some risk and this includes prescription meds such as C/L and popular supplements such as HDT. Not trying to scare anyone, just trying to show some of what has been seen as regards Trehalose. Well, if you eat that blueberry in front of a bear, you may have a problem! □ Glad to see you back, Joe, it has been a minute! Looks like I will be adding to my smoothie. if you scroll down past the abstract it shows a bunch of citations with cool factoids. There is also this article from 2017 Autophagy induction by trehalose: Molecular mechanisms and therapeutic impacts /publicatio. seems to indicate taking 100 grams a day does make it into your blood. from 2020 that says you can't take Trehalose orally, but that confuses me because sunvox linked to /pmc/articl. I did find this article "Natural Compounds and Autophagy: Allies Against Neurodegeneration" /articles/10. Neuroprotective Effects of Trehalose and Sodium Butyrate on Preformed Fibrillar Form of α-Synuclein-Induced Rat Model of Parkinson’s Disease - 2021 /doi/10.1021/ac. I did my own searching and found Trehalose as a promising therapeutic candidate for the treatment of Parkinson's disease - 2019 /pmc/articl. Hats off to sunvox for having mentioned Trehalose a few times in these forums /ataxia-u.
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